教学方向：

《现代生物学技术》
《科研方法与写作》

研究领域：

功能核酸和肿瘤精准分子医药

研究方向：

功能核酸

核酸纳米器件

细胞成像

精准分子医药

体内细胞编辑与免疫治疗

生理过程及病理机制分子调控

肿瘤分子靶向精准治疗

个人简介：

吴再生，VSport体育教授、博导，学科领军人才，国家海外高层次人才，检验医学教育部重点实验室主任，功能核酸和肿瘤精准分子医药团队负责人，中国化学会高级会员。入选过福建省级高层次人才（B 类）、福建省高层次创业创新人才（百人计划）、福建省闽江学者特聘教授、福建省高校领军人才和河南省高等公司特聘教授等；曾是加拿大麦克马斯特大学医公司特聘博士后、蒙特利尔生物科学与生物技术有限公司首席研究员(Principal Scientist, Bio S&T in Montreal, Canada)。致力于功能核酸探针、核酸纳米器件、癌症早期诊断、分子靶向精准治疗和细胞免疫治疗等领域的研究，发表SCI论文150多篇，其中在Nat. Commun.、J. Am. Chem. Soc.和Angew. Chem. Int. Ed.等中科院 JCR一区期刊SCI论文100多篇。获授权国家发明专利9件；参编英文论著1部。曾获福建省青年科技奖与湖南省化学化工会青年化学化工奖等奖项，是获得加拿大麦克马斯特大学Michael G. DeGroote国际人才重点专项基金的第一位中国学者。主持国家级或其它级别项目20多项；培养或联合培养博士后和硕博研究生等110余名，其中部分晋升教授、博导，并入选国家级或省级人才计划。

代表性学术论文:

1. Weijun Wang, Yanru Chen, Jingting Wu, Jinrui Lv, Yaxin Chen, Mengling Lin, Ran Liu, Hongwei Yin, and Zai-Sheng Wu,* Programmable DNA Dendrimer from a Single Symmetric Y-Shaped Structural Unit for Targeted Tumor Therapy with One Hundred Inhibition Efficiency, Adv. Funct. Mater. Advanced Functional Materials, 2025, 2421245

2. Weijun Wang, Wenqing Wang, Yaxin Chen, Mengling Lin, Yan-Ru Chen, Ruijin Zeng, Tenghang He, Zhifa Shen, Zai-Sheng Wu*, Superlarge, Rigidified DNA Tetrahedron with a Y-Shaped Backbone for Organizing Biomolecules Spatially and Maintaining Their Full Bioactivity, ACS Nano, 2024, 18, 28, 18257–18281

3. Wenhao Pan, Huimin Niu, Shasha Luo, Linhuan Chen, and Zai-Sheng Wu*, Intelligent reconfiguration-promoted cellular internalization of core-shell DNA nanoprobe equipped with successive dual stimuli-responsive protective satellites for amplification fluorescence imaging of tumor cells, Small, 2024, e2311388

4. Wang, Weijun; Lin, Mengling; Chen, Yan-Ru; Wang, Wenqing; Lv, Jinrui; Chen, Yaxin; Yin, Hongwei; Shen, Zhifa; Wu, Zai-Sheng,* Y-Shaped Backbone-Rigidified DNA Tiles for the Construction of Supersized Nondeformable Tetrahedrons for Precise Cancer Therapies, Analytical Chemistry, 2024, 96, 4, 1488–1497

5. Weijun Wang, Mengling Lin, Wenqing Wang, Zhifa Shen, Zai-Sheng Wu*, DNA tetrahedral nanostructures for the biomedical application and spatial orientation of biomolecules, Bioactive Materials, 2024, 33, 279-310

6. Jingting Wu, Ran Liu, Xiaoqi Zheng, Linhuan Chen and Zai-Sheng Wu*, Shell penetration/free energy-driven crosstalk between intelligent DNA nanomachines for ultrasensitive detection of circulating tumor cells, Nano Today, 2023, 49, 101808

7. Congcong Li, Yansha Gao, Qian Li, Shasha Luo, Wenqiang Liao and Zai-Sheng Wu*, Adhesive AuNP tape-mediated hierarchical assembly of multicenter DNA nanocomplexes for tumor cell nucleus-targeted staged drug delivery in vivo, Nano Today, 2022, 47, 101687

8. Weijun Wang, Yansha Gao, Yaxin Chen, Wenqing Wang, Qian Li, Zhiyi Huang, Jingjing Zhang, Qi Xiang, Zai-Sheng Wu*, Outward Movement of Targeting Ligands from a Built-In Reserve Pool in Nuclease-Resistant 3D Hierarchical DNA Nanocluster for in Vivo High-Precision Cancer Therapy, Advanced Science, 2022, 9 (33), e2203698

9. Chang Xue, Shuyao Hu, Zhi-Hua Gao, Lei Wang, Meng-Xue Luo, Xin Yu, Bi-Fei Li, Zhifa Shen & Zai-Sheng Wu*, Programmably tiling rigidified DNA brick on gold nanoparticle as multi-functional shell for cancer-targeted delivery of siRNAs, Nature Communications, 2021, 2928

10. Yansha Gao, Songbai Zhang, Chengwei Wu, Qian Li, Zhifa Shen ,Yi Lu,* Zai-Sheng Wu,* Self-Protected DNAzyme Walker with a Circular Bulging DNA Shield for Amplified Imaging of miRNAs in Living Cells and Mice, ACS Nano, 2021, 15, 12, 19211–19224

11. Ran Liu, Songbai Zhang, Ting-Ting Zheng, Yan-Ru Chen, Jing-Ting Wu, and Zai-Sheng Wu*, Intracellular Nonenzymatic In Situ Growth of Three-Dimensional DNA Nanostructures for Imaging Specific Biomolecules in Living Cells, ACS Nano, 2020, 14, 8, 9572–9584

12. Chang Xue, Songbai Zhang, Xin Yu, Shuyao Hu, Yi Lu,* and Zai-Sheng Wu*, Periodically Ordered, Nuclease-Resistant DNA Nanowires Decorated with Cell-Specific Aptamers as Selective Theranostic Agents, Angewandte Chemie International Edition, 2020, 59, 17540-17547

13. Shuxin Zhang, Chang Chen, Chang Xue, Dingran Chang, Huo Xu, Bruno J. Salena, Yingfu Li* and Zai-Sheng Wu*, Ribbon of DNA Lattice on Gold Nanoparticles for Selective Drug Delivery to Cancer Cell, Angewandte Chemie International Edition, 2020, 59 (34), 14584-14592

14. Changhe Ouyang, Songbai Zhang, Chang Xue, Xin Yu, HuoXu, Zhenmeng Wang, Yi Lu,* and Zai-Sheng Wu*, Precision guided missile-like DNA nanostructure containing warhead and guidance control for aptamer-based targeted drug delivery into cancer cells in vitro and in vivo, Journal of the American Chemical Society, 2020, 142, 3, 1265-1277